effects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat
نویسندگان
چکیده
objective(s): global cerebral ischemia-reperfusion (gcir) causes disturbances in brain functions as well as other organs such as kidney. our aim was to evaluate the protective effects of ellagic acid (ea) on certain renal disfunction after gcir. materials and methods: adult male wistar rats (n=32, 250-300 g) were used. gcir was induced by bilateral vertebral and common carotid arteries occlusion (4-vo). animal groups were: 1) received dmso/saline (10%) as solvent of ea, 2) solvent + gcir, 3) ea + gcir, and 4) ea. under anesthesia with ketamine/xylazine, gcir was induced (20 and 30 min respectively) in related groups. ea (100 mg/kg, dissolved in dmso/saline (10%) or solvent was administered (1.5 ml/kg) orally for 10 consecutive days to the related groups. eeg was recorded from nts in gcir treated groups. results: our data showed that: a) eeg in gcir treated groups was flattened. b) gcir reduced gfr (p<0.01) and pretreatment with ea attenuated this reduction. c) bun was increased by gcir (p<0.001) and pretreatment with ea improved the bun to normal level. d) serum creatinine concentration was elevated by gcir but not significantly, however, in ea+gcir group serum creatinine was reduced (p<0.05). e) gcir induced proteinuria (p<0.05) but, ea was unable to reduced proteinuria. conclusion: results indicate that gcir impairs certain renal functions and ea as an antioxidant can improve these functions. our results suggest the possible usefulness of ellagic acid in patients with brain stroke.
منابع مشابه
Effects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat
Objective(s): Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. Materials and Methods: Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusio...
متن کاملEffects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat
OBJECTIVES Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. MATERIALS AND METHODS Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusion ...
متن کاملTherapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats
Objectives: Curcumin has anti-inflammatory and antioxidative properties. The objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (I/R). Materials and Methods: Animals were randomly divided into 9 groups. The groups with 24-h reperfusion consisted of sham-24h,...
متن کاملPretreatment effects of metformin on behavioral manifestations of global ischemia/reperfusion injury in rats
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
متن کاملThe Study of Petoxifylline Drug Effects on Renal Apoptosis and Bcl2 Gene Expression Changes Following Ischemic Reperfusion Injury in Rat
Background & Target: Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.Methods: In this experimental study, 20 male wistar rats with average weight of...
متن کاملThe Study of Petoxifylline Drug Effects on Renal Apoptosis and Bcl2 Gene Expression Changes Following Ischemic Reperfusion Injury in Rat
Background & Target: Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.Methods: In this experimental study, 20 male wistar rats with average weight of...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۲۰، شماره ۱، صفحات ۷۵-۸۲
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023